“Some men look at constitutions with sanctimonious reverence, and deem them like the ark of the covenant, too sacred to be touched. They ascribe to the men of the preceding age a wisdom more than human, and suppose what they did to be beyond amendment. I knew that age well; I belonged to it, and labored with it. It deserved well of its country. It was very like the present, but without the experience of the present; and forty years of experience in government is worth a century of book-reading; and this they would say themselves, were they to rise from the dead. I am certainly not an advocate for frequent and untried changes in laws and constitutions. I think moderate imperfections had better be borne with; because, when once known, we accommodate ourselves to them, and find practical means of correcting their ill effects. But I know also, that laws and institutions must go hand in hand with the progress of the human mind. As that becomes more developed, more enlightened, as new discoveries are made, new truths disclosed, and manners and opinions change with the change of circumstances, institutions must advance also, and keep pace with the times. We might as well require a man to wear still the coat which fitted him when a boy, as civilized society to remain ever under the regimen of their barbarous ancestors.” 

“A little rebellion now and then is a good thing.”

“It is error alone which needs the support of government. Truth can stand by itself.”

“I am not a Federalist because I never submitted the whole system of my opinions to the creed of any party of men whatever....Such an addiction is the last degradation of a free and moral agent. If I could not go to heaven but with a party, I would not go there at all.”

“I steer my bark with Hope in the head, leaving Fear astern. My hopes, indeed, sometimes fail; but not oftener than the forebodings of the gloomy.”

“Always take hold of things by the smooth handle.”

“...it is not to be understood that I am with him [Jesus] in all his doctrines. I am a Materialist, he takes the side of spiritualism; he preaches the efficacy of repentance toward forgiveness of sin. I require a counterpoise of good works to redeem it... Among the sayings & discourses imputed to him by his biographers, I find many passages of fine imagination, correct morality, and of the most lovely benevolence: and others again of so much ignorance, so much absurdity, so much untruth, charlatanism, and imposture, as to pronounce it impossible that such contradictions should have proceeded from the same being.

“In every country and every age, the priest had been hostile to Liberty.”

“He who permits himself to tell a lie once, finds it much easier to do it the second time.”

“I may grow rich by an art I am compelled to follow; I may recover health by medicines I am compelled to take against my own judgment; but I cannot be saved by a worship I disbelieve and abhor.”

“Self-love is no part of morality. Indeed it is exactly its counterpart. It is the sole antagonist of virtue leading us constantly by our propensities to self-gratification in violation of our moral duties to others.”

“the measure of society is how it treats the weakest members”

“To compel a man to subsidize with his taxes the propagation of ideas which he disbelieves and abhors is sinful and tyrannical.”

“May I never get too busy in my own affairs that I fail to respond to the needs of others with kindness and compassion.”

“A machine for making revolutions is doing precisely the wrong thing at just the right time.”