“our civil rights have no dependance on our religious opinions, any more than our opinions in physics or geometry; that therefore the proscribing any citizen as unworthy the public confidence by laying upon him an incapacity of being called to offices of trust and emolument, unless he profess or renounce this or that religious opinion, is depriving him injuriously of those privileges and advantages to which, in common with his fellow citizens, he has a natural right; that it tends also to corrupt the principles of that very religion it is meant to encourage,”

“Every human being must be viewed according to what it is good for. For not one of us, no, not one, is perfect. And were we to love none who had imperfection, this world would be a desert for our love.” 

“Health, learning and virtue will ensure your happiness; they will give you a quiet conscience, private esteem and public honour.”

“It is an axiom in my mind, that our liberty can never be safe but in the hands of the people themselves, and that too of the people with a certain degree of instruction. This it is the business of the State to effect, and on a general plan.”

“Some men look at constitutions with sanctimonious reverence, and deem them like the ark of the covenant, too sacred to be touched. They ascribe to the men of the preceding age a wisdom more than human, and suppose what they did to be beyond amendment. I knew that age well; I belonged to it, and labored with it. It deserved well of its country. It was very like the present, but without the experience of the present; and forty years of experience in government is worth a century of book-reading; and this they would say themselves, were they to rise from the dead. I am certainly not an advocate for frequent and untried changes in laws and constitutions. I think moderate imperfections had better be borne with; because, when once known, we accommodate ourselves to them, and find practical means of correcting their ill effects. But I know also, that laws and institutions must go hand in hand with the progress of the human mind. As that becomes more developed, more enlightened, as new discoveries are made, new truths disclosed, and manners and opinions change with the change of circumstances, institutions must advance also, and keep pace with the times. We might as well require a man to wear still the coat which fitted him when a boy, as civilized society to remain ever under the regimen of their barbarous ancestors.” 

“When describing the University of Virginia: Here, We are not afraid to follow truth wherever it may lead, nor to tolerate any error so long as reason is left free to combat it.”

“If by religion we are to understand sectarian dogmas, in which no two of them agree, then your exclamation on that hypothesis is just, "that this would be the best of worlds if there were no religion in it.” 

“Every citizen should be a soldier. This was the case with the Greeks and Romans, and must be that of every free state.”

“It is neither wealth nor splendor, but tranquility and occupation which give happiness.”

“No free man shall ever be debarred the use of arms”

“Honesty is the first chapter of the book wisdom.”

“There is a natural aristocracy among men. The grounds of this are virtue and talents.”

“Perceiving the order of nature to be that individual happiness shall be inseparable from the practice of virtue, I am willing to hope it may have ordained that the fall of the wicked shall be the rise of the good.  To J. Correa de Serra, Monticello, Apr. 19, 1814”

“Every generation needs a new revolution.”

“You are now old enough to know how very important to your future life will be the manner in which you employ your present time”