“There exists indeed an opposition to it [building of UVA, Jefferson's secular college] by the friends of William and Mary, which is not strong. The most restive is that of the priests of the different religious sects, who dread the advance of science as witches do the approach of day-light; and scowl on it the fatal harbinger announcing the subversion of the duperies on which they live. In this the Presbyterian clergy take the lead. The tocsin is sounded in all their pulpits, and the first alarm denounced is against the particular creed of Doctr. Cooper; and as impudently denounced as if they really knew what it is.

“There is not a truth existing which I fear, or would wish unknown to the whole world.”

“History, by apprising [the people] of the past, will enable them to judge of the future.” 

“I never will, by any word or act, bow to the shrine of intolerance or admit a right of inquiry into the religious opinions of others.”

“...it is not to be understood that I am with him [Jesus] in all his doctrines. I am a Materialist, he takes the side of spiritualism; he preaches the efficacy of repentance toward forgiveness of sin. I require a counterpoise of good works to redeem it... Among the sayings & discourses imputed to him by his biographers, I find many passages of fine imagination, correct morality, and of the most lovely benevolence: and others again of so much ignorance, so much absurdity, so much untruth, charlatanism, and imposture, as to pronounce it impossible that such contradictions should have proceeded from the same being.

“It is more dangerous that even a guilty person should be punished without the forms of law than that he should escape.”

“...never [enter] into dispute or argument with another. I never saw an instance of one of two disputants convincing the other by argument. I have seen many, on their getting warm, becoming rude, & shooting one another. ... When I hear another express an opinion which is not mine, I say to myself, he has a right to his opinion, as I to mine; why should I question it? His error does me no injury, and shall I become a Don Quixote, to bring all men by force of argument to one opinion? ... There are two classes of disputants most frequently to be met with among us. The first is of young students, just entered the threshold of science, with a first view of its outlines, not yet filled up with the details & modifications which a further progress would bring to their knoledge. The other consists of the ill-tempered & rude men in society, who have taken up a passion for politics. ... Consider yourself, when with them, as among the patients of Bedlam, needing medical more than moral counsel. Be a listener only, keep within yourself, and endeavor to establish with yourself the habit of silence, especially on politics. In the fevered state of our country, no good can ever result from any attempt to set one of these fiery zealots to rights, either in fact or principle. They are determined as to the facts they will believe, and the opinions on which they will act. Get by them, therefore, as you would by an angry bull; it is not for a man of sense to dispute the road with such an animal.”

“But friendship is precious, not only in the shade but in the sunshine of life; & thanks to a benevolent arrangement of things, the greater part of life is sunshine. I will recur for proof to the days we have lately passed. On these indeed the sun shone brightly.”

“How little do my countrymen know what precious blessings they are in possession of, and which no other people on earth enjoy!” 

“The art of life is the art of avoiding pain; and he is the best pilot, who steers clearest of the rocks and shoals with which it is beset.”

“While the art of printing is left to us science can never be retrograde; what is once acquired of real knowledge can never be lost.”

“Those who expect to be both ignorant and free, expect what never was and never will be.” 

“A wise and frugal Government, which shall restrain men from injuring one another, which shall leave them otherwise free to regulate their own pursuits of industry and improvement, and shall not take from the mouth of labor the bread it has earned. This is the sum of good government, and this is necessary to close the circlue of our felicities.”

“The principle of spending money to be paid by posterity, under the name of funding, is but swindling futurity on a large scale.”

“The whole art of government consists in the art of being honest. Only aim to do your duty, and mankind will give you credit where you fail.”