“The rich alone use imported articles, and on these alone the whole taxes of the General Government are levied...and its surplus applied to canals, roads, schools, etc., the farmer will see his government supported, his children educated, and the face of his country made a paradise by the contributions of the rich alone, without his being called on to spend a cent from his earnings.”

“The main objects of all science, the freedom and happiness of man. . . . [are] the sole objects of all legitimate government.

“Follow truth wherever it may lead you.”

“I am a sect by myself, as far as I know.”

“If a nation expects to be ignorant and free, in a state of civilization, it expects what never was and never will be.”

“Be polite to all, but intimate with few.”

“When describing the University of Virginia: Here, We are not afraid to follow truth wherever it may lead, nor to tolerate any error so long as reason is left free to combat it.”

“The contest is not between Us and Them, but between Good and Evil, and if those who would fight Evil adopt the ways of Evil, Evil wins.”

“Do not be too severe upon the errors of the people, but reclaim them by enlightening them.”

“Some men look at constitutions with sanctimonious reverence, and deem them like the ark of the covenant, too sacred to be touched. They ascribe to the men of the preceding age a wisdom more than human, and suppose what they did to be beyond amendment. I knew that age well; I belonged to it, and labored with it. It deserved well of its country. It was very like the present, but without the experience of the present; and forty years of experience in government is worth a century of book-reading; and this they would say themselves, were they to rise from the dead. I am certainly not an advocate for frequent and untried changes in laws and constitutions. I think moderate imperfections had better be borne with; because, when once known, we accommodate ourselves to them, and find practical means of correcting their ill effects. But I know also, that laws and institutions must go hand in hand with the progress of the human mind. As that becomes more developed, more enlightened, as new discoveries are made, new truths disclosed, and manners and opinions change with the change of circumstances, institutions must advance also, and keep pace with the times. We might as well require a man to wear still the coat which fitted him when a boy, as civilized society to remain ever under the regimen of their barbarous ancestors.” 

“He who knows best knows how little he knows.”

“I almost shudder at the thought of alluding to the most fatal example of the abuses of grief which the history of mankind has preserved - the Cross. Consider what calamities that engine of grief has produced! With the rational respect that is due to it, knavish priests have added prostitutions of it, that fill or might fill the blackest and bloodiest pages of human history.

“All that is necessary for a student is access to a library.”

“Whiskey claims to itself alone the exclusive office of sot-making.”

“I have examined all the known superstitions of the world,and I do not find in our particular superstition of Christianity one redeeming feature. They are all alike founded on fables and mythology. Millions of innocent men women and children since the introduction of Christianity,have been burnt, tortured, fined and imprisoned. What has been the effect of this coercion? To make one half the world fools and the other half hypocrites; to support roguery and error all over the earth.”