“That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness.”

“While the art of printing is left to us science can never be retrograde; what is once acquired of real knowledge can never be lost.”

“Some men look at constitutions with sanctimonious reverence, and deem them like the ark of the covenant, too sacred to be touched. They ascribe to the men of the preceding age a wisdom more than human, and suppose what they did to be beyond amendment. I knew that age well; I belonged to it, and labored with it. It deserved well of its country. It was very like the present, but without the experience of the present; and forty years of experience in government is worth a century of book-reading; and this they would say themselves, were they to rise from the dead. I am certainly not an advocate for frequent and untried changes in laws and constitutions. I think moderate imperfections had better be borne with; because, when once known, we accommodate ourselves to them, and find practical means of correcting their ill effects. But I know also, that laws and institutions must go hand in hand with the progress of the human mind. As that becomes more developed, more enlightened, as new discoveries are made, new truths disclosed, and manners and opinions change with the change of circumstances, institutions must advance also, and keep pace with the times. We might as well require a man to wear still the coat which fitted him when a boy, as civilized society to remain ever under the regimen of their barbarous ancestors.” 

“A library book lasts as long as a house, for hundreds of years. It is not an article for mere consumption, but fairly of capital, and often in the case of professional men, setting out in life, it is their only capital.”

“The object most interesting to me for the residue of my life, will be to see you both developing daily those principles of virtue and goodness which will make you valuable to others and happy in yourselves, and acquiring those talents and that degree of science which will guard you at all times against ennui, the most dangerous poison of life. A mind always employed is always happy. This is the true secret, the grand recipe for felicity....In a world which furnishes so many employments which are useful, and so many which are amusing, it is our own fault if we ever know what ennui is...”

“When I hear another express an opinion which is not mine, I say to myself, he has a right to his opinion, as I to mine. Why should I question it? His error does me no injury, and shall I become a Don Quixote, to bring all men by force of argument to one opinion? ...Be a listener only, keep within yourself, and endeavor to establish with yourself the habit of silence, especially in politics.”

“The happiest moments of my life have been the few which I have passed at home in the bosom of my family.”

“The dead should not rule the living.”

“Difference of opinion is advantageous in religion. The several sects perform the office of a Censor morum over each other. Is uniformity attainable? Millions of innocent men, women, and children, since the introduction of Christianity, have been burnt, tortured, fined, imprisoned; yet we have not advanced one inch towards uniformity. What has been the effect of coercion? To make one half the world fools, and the other half hypocrites. To support roguery and error all over the earth. Let us reflect that it is inhabited by a thousand millions of people. That these profess probably a thousand different systems of religion. That ours is but one of that thousand. That if there be but one right, and ours that one, we should wish to see the 999 wandering sects gathered into the fold of truth. But against such a majority we cannot effect this by force. Reason and persuasion are the only practicable instruments. To make way for these, free enquiry must be indulged; and how can we wish others to indulge it while we refuse it ourselves.”

“The policy of the American government is to leave its citizens free, neither restraining them nor aiding them in their pursuits.”

“There is not a truth existing which I fear, or would wish unknown to the whole world.”

“It is more dangerous that even a guilty person should be punished without the forms of law than that he should escape.”

“Whiskey claims to itself alone the exclusive office of sot-making.”

“all experience hath shewn, that mankind are more disposed to suffer, while evils are sufferable, than to right themselves by abolishing the forms to which they are accustomed.”

“Importation of such Persons as any of the States now existing shall think proper to admit, shall not be prohibited by the Congress prior to the Year one thousand eight hundred”